The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell
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The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell
AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411. Cell-surfa...
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ژورنال
عنوان ژورنال: International Journal of Antimicrobial Agents
سال: 2016
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2016.01.016